A publication by Leslie Sombers, Ph.D., M.A., a professor of cellular and systems pharmacology in the UF College of Pharmacy, was highlighted on the cover of ACS Chemical Neuroscience. The cover art was designed by former Sombers Lab member J. Dylan Denison.
ACS Chemical Neuroscience
Progress toward Multianalyte Neurochemical Detection: Techniques and Applications
To date, sensing strategies for monitoring neurochemical dynamics have almost all been specifically designed to target a single analyte at a time. This is striking, because many brain neurochemicals fluctuate in response to environmental cues, sensory inputs, and learned associations, and the precise timing of these signals corresponds with specific functional outcomes. In this sense, studying brain function by monitoring one neurochemical at a time can be likened to an attempt at appreciating a musical piece that was written for a full orchestra by listening to only one instrument at a time. Shifting the standard paradigm to simultaneous co-detection of multiple species at the same place and time promises to provide important and unprecedented perspective.